商品名:Bexacat (Elanco)
Bexagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. SGLT2 is responsible for reabsorption of glucose from the renal glomerular filtrate. By inhibiting SGLT2, bexagliflozin reduces renal glucose reabsorption and lowers the renal threshold for glucose, increasing urinary glucose excretion (glycosuria). This achieves glycemic control without exogenous insulin, potentially allowing pancreatic beta-cell recovery from glucotoxicity.
Improvement of glycemic control in otherwise healthy cats with diabetes mellitus not previously treated with insulin. First oral antidiabetic and first SGLT2 inhibitor approved for any animal species (FDA December 2022).
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
本品只適用於完成篩檢且從未用過胰島素的特定糖尿病貓;曾用/現用胰島素、胰島素依賴、肝病或腎功能下降均會改變可用性。現有計算器不能強制物種、3.0 kg 美國產品下限、胰島素史、食慾、水合、酮體/酸鹼、胰臟與腎肝條件,因此封鎖自助計算與飼主劑量,也不得換算成 mg/kg 或外推至犬。
DRUGAPI 劑量審查引用的獸醫官方標示(各標示只適用於其產品、物種與法域,不可互換)
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。