商品名：Simplicef (veterinary preparation), Vantin (human
Cephalosporin antibiotic. Action is similar to other beta-lactam antibiotics, which inhibit synthesis of bacterial cell wall leading to cell death. Cephalosporins are divided into first-, second-, third-, and fourth-generation drugs depending on spectrum of activity. Cefpodoxime is a third-generation cephalosporin, which indicates greater activity against gram-negative bacilli compared to first-generation cephalosporins. However, cefpodoxime is not as active against many gram-negative bacilli as injectable third-generation cephalosporins such as cefotaxime or ceftazidime. Cefpodoxime has better activity against Staphylococcus than other oral third-generation cephalosporins. It is not active against Enterococcus spp., methicillin-resistant Staphylococcus spp., or Pseudomonas aeruginosa. Act
Cefpodoxime is indicated for treatment of skin and other soft tissue infections in dogs caused by susceptible organisms. Efficacy has been established in dogs for treatment of skin and soft tissue infections. Cefpodoxime has greater activity against gram-negative bacilli than first-generation cephalosporins; therefore, it may be effective for some gram-negative infections. Although not currently registered for treatment of UTIs, approximately 50% of administered dose is excreted in urine and expected to be active for treating UTIs caused by common pathogens. Cefpodoxime Proxetil 127 C Although not registered for cats, or tested in cats, no adverse effects have been reported from occasional use. However, oral absorption in cats has not been examined.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
確認 cefpodoxime proxetil 前驅藥、活性 cefpodoxime 效價基準、商品、標示者、強度、刻痕、容器、保存與供貨狀態 確認物種為犬，並核對體重、年齡、感染部位、膿皮症深度、傷口或膿瘍狀態、檢體、細胞學、病原、菌株、感受性方法與適用判讀標準 區分經驗性與目標性治療，先評估局部治療、underlying cause、地區抗藥性、替代方案、抗菌藥管理與法域限制 確認 cefpodoxime、頭孢菌素與其他 β-內醯胺過敏史、腎肝功能、水合、生殖狀態及所有藥品與補充品 建立臨床反應、新病灶、治療失敗、過敏、腸胃、腎臟、二重感染、檢驗干擾及停換藥的個別監測計畫
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
63%
7 hours