商品名：Prozac (human formulation); Reconcile (veterinary
Antidepressant drug. Fluoxetine, like other drugs in this class, is classified as a selective serotonin reuptake inhibitor (SSRI). Its mechanism of action appears to be via selective inhibition of serotonin reuptake and downregulation of 5-HT1 receptors. SSRIs are more selective for inhibiting serotonin reuptake than the tricyclic antidepressant (TCA) drugs. Fluoxetine is metabolized to norfluoxetine, which is an active metabolite. Oral absorption in dogs is 72% with a half-life of 6-10 hours. The metabolite norfluoxetine has a longer half-life of 48-57 hours. In cats, oral absorption is 100%
Fluoxetine, like other SSRIs, is used to treat behavioral disorders such as separation anxiety, canine compulsive behaviors, and dominance aggression. In cats, it has been effective for decreasing urine spraying (1 mg/kg/day). In trials comparing fluoxetine with clomipramine for treating urine marking in cats, both drugs were equally effective for long-term use. In both dogs and cats SSRI have been used for pain syndromes, but there are no studies of efficacy published for this indication. However, the urine marking returned after discontinuation of the drug. Fluoxetine Hydrochloride 327 F In
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