商品名：Glucotrol
Sulfonylurea oral hypoglycemic agent. This drug acts to increase secretion of insulin from beta cells of the pancreas, probably by interacting with sulfonylurea receptors on beta cells or by inhibiting adenosine triphosphate (ATP)–sensitive potassium channels on the pancreatic beta cells, which increases insulin secretion. These drugs also may increase sensitivity of existing insulin receptors. Studies in cats showed that glipizide had a half-life of 17 hours and effective plasma concentration for 50% efficacy (EC50) of 70 mcg/mL.
Glipizide is used as oral treatment in the management of diabetes mellitus, particularly in cats. Response rate in cats is approximately 44%-65% (some reports are 30% or lower). The response rate in dogs is poor. It has been more common to administer the sulfonylurea class of drugs in animals than other oral hypoglycemic drugs because they have had better efficacy. Glipizide is the most common of this class. Other oral hypoglycemic drugs include acetohexamide, chlorpropamide, glyburide (DiaBeta, Micronase), gliclazide, and tolazamide. Metformin is of the biguanide class of oral drugs for diabe
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
必須先確認現行指南所支持的糖尿病治療選項與個別病例適用性 必須核對確切活性成分、劑型、釋放型態與是否為複方 若有例外使用評估，必須由獸醫建立病例專屬處方、監測與緊急處置計畫
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
2-4 hours
renal