商品名：Vfend
Azole (triazole) antifungal drug. Voriconazole is a second-generation triazole antifungal drug. Similar to the other currently available azole and triazole antifungals, voriconazole inhibits the fungal cytochrome P450-dependent 14 alpha-sterol demethylase, which is essential for formation of ergosterol in the fungal 810 Voriconazole cell wall. Voriconazole is similar in structure to fluconazole; however, it is more active and potent. Voriconazole is active against dermatophytes and systemic fungi, such as Blastomyces, Histoplasma, and Coccidioides. It also has activity against yeast, such as Candida and Malassezia. Voriconazole has greater activity against Aspergillus and Fusarium than other drugs of this class and is indicated for systemic treatment. Voriconazole is more lipophilic than f
Voriconazole has been used to treat dermatophytes and systemic fungi, such as Blastomyces, Histoplasma, and Coccidioides. It has been used to treat infections caused by Aspergillus and Fusarium. The efficacy in humans for treating Aspergillus is better than with other oral antifungal drugs and comparable to amphotericin B. Penetration into the CNS and eye is high enough to treat infections in these areas. Most of the use in veterinary medicine has been empirical or extrapolated from the use in humans. Clinical experience in horses has used a dose of 2 mg/kg once-daily PO. But research studies have showed that a dose of 4 mg/kg once daily, PO, or a dose of 3 mg/kg q12h, PO, produces adequate in plasma and tissue concentrations (ocular tear film, CSF, urine, epithelial lining fluid of the lu
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
公開獸醫證據受物種、感染、處置、產品與研究設計嚴格限制。貓的蓄積／神經毒性、犬隻清創加 TDM 情境、健康馬 PK 與鳥類種間差異，使本條目不能提供通用可執行劑量或通用濃度目標。
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。