商品名:Parlodel
Dopaminergic agonist. Antiprolactin agent. Bromocriptine is a lactation inhibitor. It reduces serum prolactin concentration by inhibition of release from anterior pituitary gland by binding to dopamine (D2) receptors in the CNS. The binding of D2 receptors restores hormonal function in the pituitary. Through the action on the dopamine pituitary receptors, bromocriptine may decrease corticotropin (ACTH) release and has been used in animals (especially horses) for treating pituitary- dependent hyperadrenocorticism (PDH). It has not been effective for treating canine pituitary-dependent hyperadrenocorticism (Cushing’s syndrome). It also stimulates postsynaptic dopamine receptors and has been used to treat dopamine- deficient neurodegenerative diseases.
In people, bromocriptine is used for its antiparkinson effect and to inhibit lactation associated with excess prolactin. It also has been used to treat acromegaly. Bromocriptine has been used to treat disorders associated with dopamine deficiency in animals. In dogs, bromocriptine has been used to terminate pregnancy when used in combination with a prostaglandin (dinoprost or cloprostenol). In this combination, it was 100% effective for terminating pregnancy in dogs. In horses, bromocriptine may decrease ACTH release and has been used in treating equine pituitary pars intermedia dysfunction (Cushing’s syndrome), but pergolide is usually a preferred treatment.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
現行犬原始劑量文字已截斷,structured rows 又互相衝突;終止妊娠研究依孕期與 prostaglandin 組合而異,單方並非一致有效。貓 hypersomatotropism 與馬 PPID 的數值未由本輪現行公開來源支持。通用 calculator、處方與飼主自選量全部封鎖。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。