氯法齊明 Clofazimine

商品名：Lamprene

AntibacterialClofazimine is available in 50- and 100-mg capsules.犬貓

藥理 Pharmacology

作用機轉

Antimicrobial agent used to treat feline leprosy. It produces a slow bactericidal effect on Mycobacterium leprae.

適應症

Clofazimine has had limited use in veterinary medicine. Its use is limited to treating infections caused by Mycobacterium, such as feline leprosy.

劑量 Dosage

劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。

DRUGAPI 劑量審查

用藥前須確認的事項（DRUGAPI 審查結論）

執行前必須由獸醫師核對精確成分與商品、強度與載體、物種與病患、感染部位與範圍、分枝桿菌種與菌株、培養及感受性方法、單用或複方、給藥途徑、心律與肝腸眼皮膚風險、監測、抗菌藥物管理、實際取得途徑及法域；公開證據不足以建立通用犬貓執行契約。

其他引用來源（5）

Treatment of localized Mycobacterium avium complex infection with clofazimine and doxycycline in a catJournal of the American Veterinary Medical Association; PubMed PMID 7591945
Treatment of canine leproid granuloma syndrome: preliminary findings in seven dogsAustralian Veterinary Journal; PubMed PMID 11221566
Feline Leprosy: Two Different Clinical SyndromesJournal of Feline Medicine and Surgery; PubMed Central PMCID PMC10829152
First report of Mycobacteria avium complex (Mycobacteria intracellulare) in a cat from Southeast AsiaJournal of Feline Medicine and Surgery Open Reports; PubMed Central PMCID PMC10559717
DailyMed - LAMPRENE - clofazimine capsule, liquid filled人醫U.S. National Library of Medicine, DailyMed; labeler Novartis Pharmaceuticals Corporation

副作用 Adverse Effects

依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。

常見（>10%）— 經常出現，臨床上多數病例會見到

emesis(monitor)
腹瀉(monitor)
elevation of liver enzymes(monitor)
sedation/lethargy/depression(monitor)
dry mouth(monitor)
etc.(monitor)
anticholinergic effects(monitor)
鎮靜(monitor)
sedation of clomipramine than dogs(monitor)
食慾不振(monitor)
嗜睡(monitor)
精神沉鬱(monitor)
心搏過速(monitor)

藥物動力學 Pharmacokinetics

排泄途徑

renal

交互作用

Cimetidine⛔ 高風險

May inhibit tricyclic antidepressant metabolism and increase the risk of toxicity

Monoamine Oxidase Inhibitors⛔ 高風險

Concomitant use (within 14 days) with monoamine oxidase inhibitors is generally contraindicated (serotonin syndrome)

Cisapride⚠️ 中風險

Increased risk for prolonged QT interval

Clonidine⚠️ 中風險

May cause increased blood pressure

Meperidine, Pentazocine, Dextromethorphan⚠️ 中風險

Increased risk for serotonin syndrome

Rifampin⚠️ 中風險

May decrease tricyclic blood levels

SSRIs⚠️ 中風險

Increased risk for serotonin syndrome

Sympathomimetic Agents⚠️ 中風險

Use in combination with sympathomimetic agents may increase the risk of cardiac effects (arrhythmias, hypertension, hyperpyrexia)

Anticholinergic Agents✅ 低風險

Because of additive effects, use with clomipramine cautiously

CNS Depressants✅ 低風險

Because of additive effects, use with clomipramine cautiously

文中提及此藥物的疾病

以下疾病在內文（治療/用藥/處置段）引用了 Clofazimine，但尚未建立結構化關聯，僅供探索用。

貓麻風症候群分枝桿菌感染貓麻風分枝桿菌

同類藥物（Antibacterial）

阿莫西林Amoxicillin 阿莫西林克拉維酸鉀Amoxicillin + Clavulanate Potassium 阿莫西林Amoxycillin 氨苄西林Ampicillin, Ampicillin Sodium 阿托伐醌Atovaquone

劑量 Dosage

DRUGAPI 劑量審查

用藥前須確認的事項（DRUGAPI 審查結論）

其他引用來源（5）

Treatment of localized Mycobacterium avium complex infection with clofazimine and doxycycline in a catJournal of the American Veterinary Medical Association; PubMed PMID 7591945
Treatment of canine leproid granuloma syndrome: preliminary findings in seven dogsAustralian Veterinary Journal; PubMed PMID 11221566
Feline Leprosy: Two Different Clinical SyndromesJournal of Feline Medicine and Surgery; PubMed Central PMCID PMC10829152
First report of Mycobacteria avium complex (Mycobacteria intracellulare) in a cat from Southeast AsiaJournal of Feline Medicine and Surgery Open Reports; PubMed Central PMCID PMC10559717
DailyMed - LAMPRENE - clofazimine capsule, liquid filled人醫U.S. National Library of Medicine, DailyMed; labeler Novartis Pharmaceuticals Corporation

副作用 Adverse Effects

依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。

常見（>10%）— 經常出現，臨床上多數病例會見到

emesis(monitor)
腹瀉(monitor)
elevation of liver enzymes(monitor)
sedation/lethargy/depression(monitor)
dry mouth(monitor)
etc.(monitor)
anticholinergic effects(monitor)
鎮靜(monitor)
sedation of clomipramine than dogs(monitor)
食慾不振(monitor)
嗜睡(monitor)
精神沉鬱(monitor)
心搏過速(monitor)

交互作用

Cimetidine⛔ 高風險

May inhibit tricyclic antidepressant metabolism and increase the risk of toxicity

Monoamine Oxidase Inhibitors⛔ 高風險

Concomitant use (within 14 days) with monoamine oxidase inhibitors is generally contraindicated (serotonin syndrome)

Cisapride⚠️ 中風險

Increased risk for prolonged QT interval

Clonidine⚠️ 中風險

May cause increased blood pressure

Meperidine, Pentazocine, Dextromethorphan⚠️ 中風險

Increased risk for serotonin syndrome

Rifampin⚠️ 中風險

May decrease tricyclic blood levels

SSRIs⚠️ 中風險

Increased risk for serotonin syndrome

Sympathomimetic Agents⚠️ 中風險

Use in combination with sympathomimetic agents may increase the risk of cardiac effects (arrhythmias, hypertension, hyperpyrexia)

Anticholinergic Agents✅ 低風險

Because of additive effects, use with clomipramine cautiously

CNS Depressants✅ 低風險

Because of additive effects, use with clomipramine cautiously