商品名:4-Methylpyrazole, Antizol-Vet, and Antizole (human
Fomepizole is an antidote for ethylene glycol (antifreeze) and methanol intoxication. It inhibits the dehydrogenase enzyme that converts ethylene glycol to toxic metabolites.
Fomepizole is used for treatment of acute ethylene glycol toxicosis in dogs and cats. In people, it is used for this purpose but also is registered for methanol poisoning. It should be used early for maximum success. Fomepizole was safe and effective in dogs in clinical trials if used within 8 hours of poisoning. In cats, it is effective if administered at high doses within 3 hours of ethylene glycol ingestion.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
立即由急診獸醫確認確切毒物、暴露時間軸、物種、臨床階段、酸鹼與腎臟狀態。 核對目前可取得的確切成品或調製品、來源、無菌性、濃度、容器與器材,不得套用撤回套組或人用成品說明。 由獸醫毒物學團隊個別決定支持治療、監測、轉介、停止條件及是否需要其他清除措施。 歷史犬標示與犬貓研究方案只能作為不可執行證據,不得由系統或飼主自行使用。
DRUGAPI 劑量審查引用的獸醫官方標示(各標示只適用於其產品、物種與法域,不可互換)
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。
renal