商品名：Indocin
NSAID and analgesic. Like other NSAIDs, indomethacin produces potent analgesic and anti-inflammatory effects by inhibiting the synthesis of prostaglandins. The enzyme inhibited by NSAID is the cyclo-oxygenase enzyme (COX). The COX enzyme exists in two isoforms: COX-1 and COX-2. COX-1 is primarily responsible for synthesis of prostaglandins important for maintaining a healthy GI tract, renal function, platelet function, and other normal functions. COX-2 is induced and responsible for synthesizing prostaglandins that are important mediators of pain, 382 Indomethacin inflammation, and fever. However, it is known that there is some crossover of COX-1 and COX-2 effects in some situations and COX-2 activity is important for some biological effects. Indomethacin is considered a prototype for a no
Indomethacin, like other NSAIDs, has been used to treat pain and inflammation in people. However, indomethacin has not been used often in clinical veterinary medicine because other safer, registered drugs are available. Indomethacin is used as a prototypical nonselective COX-1 and COX-2 blocker in research. In dogs, the high risk of GI ulceration prohibits its routine use.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
未建立犬貓安全常規療程；現有犬 2–4、貓 0.5–1 mg/kg 與資料自身禁用註記及犬嚴重胃腸毒性證據衝突。清空劑量並阻擋計算器、處方產生與飼主劑量。
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。