商品名：Avapro
Vasodilator. Angiotensin receptor blocker (ARB). Irbesartan has been shown to block angiotensin II receptors and prevent the effects associated with angiotensin II. It has been used in people who cannot tolerate angiotension- converting enzyme (ACE) inhibitors. The metabolism in dogs and cats is uncertain and it is not known if doses extrapolated from human use have equivalent activity in dogs and cats. Losartan, another ARB, is used as an alternative in people but is reportedly not effective in dogs because they do not produce the active metabolite.
Angiotensin II blockers, such as irbesartan, are used in people as alternatives to ACE inhibitors. However, they are rarely used in animals because most animals tolerate ACE inhibitors well. Use of ARB in animals has been primarily derived from empirical use. There are no well-controlled clinical studies or efficacy trials to document clinical effectiveness.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
執行前必須核對 irbesartan 單方或 hydrochlorothiazide 複方、物種、診斷、血容量與水合、血壓、腎功能、鉀離子、蛋白尿、妊娠狀態、所有 RAAS／NSAID／利尿劑／鉀／鋰共暴露、法域與來源設計。
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。