商品名:Nitrol, Nitro-bid, and Nitrostat
Nitrate. Nitrovasodilator. Like other nitrovasodilators, it relaxes vascular smooth muscle (especially venous) via generation of nitric oxide. Nitric oxide stimulates guanylate cyclase to produce cyclic guanosine monophosphate (GMP) in vascular smooth muscle and relax smooth muscle. Nitric oxide–generating compounds may also help decrease gastric adverse effects associated with nonsteroidal anti- inflammatory drugs (NSAIDs).
Nitroglycerin, like other nitrovasodilators, is used primarily in heart failure or pulmonary edema to reduce preload or decrease pulmonary hypertension. Use in animals has been primarily derived from empirical use and experience in humans. There are no well-controlled clinical studies or efficacy trials to document clinical effectiveness. In people, they are used to treat angina pectoris. In horses, nitroglycerin has been used to improve blood flow to the feet in the management of laminitis. However, in experiments, this treatment was not effective in horses and did not increase blood flow to the feet.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
犬公開外用方案互相衝突且臨床效益證據弱,貓共識不建議;2% 軟膏、貼片、舌下錠、IV 濃縮液與 0.4% 肛內軟膏不可互換,並須執行血壓、容量與重大交互作用閘門。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。