商品名：Cozaar
Vasodilator, Angioitensin II receptor blocker (ARB). It has high affinity and selectivity for the AT1 receptor. The action is similar to that of ACE inhibitors, except that it directly blocks the receptor, rather than inhibits synthesis of angiotensin II. ARBs have the advantage of being less likely to induce hyperkalemia and are more easily tolerated in people. Losartan and other ARBs have been used in people who cannot tolerate angiotensin-converting enzyme (ACE) inhibitors. In people it is metabolized to the active carboxylic acid metabolite, which is 10-40 times more potent than the parent drug and believed to be responsible for most clinical effects. The metabolite is not produced in effective levels in dogs.
In dogs, it is reported that they do not convert losartan to the active metabolite, and therefore it has little activity in dogs. However, a related drug, irbesartan (30 mg/kg q12h), has been shown to block angiotensin II receptors.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
D0398 只保留綁定人用精確產品、現行美國動物藥索引、IRIS／Merck 專業脈絡、健康貓或實驗犬研究及次級獸醫警訊的不可執行證據。犬、貓及所有其他物種均不得由現有介面取得劑量、處方或自動交互作用結論。
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。