商品名：Isosorbide dinitrate: Isordil, Isorbid, and Sorbitrate
Nitrate vasodilator. Like other nitrovasodilators, it produces vasodilation via generation of nitric oxide. It relaxes vascular smooth muscle, especially venous. Isosorbide mononitrate is a biologically active form of isosorbide dinitrate. Compared to isosorbide dinitrate, it does not undergo first-pass metabolism and is completely absorbed orally.
Isosorbide dinitrate is used to reduce preload in patients with CHF. In people, it is primarily used to treat angina. The use in animals has not been established, and nitroglycerin is used more frequently (topically) or infusions of nitroprusside IV are used in critical care situations. Use in animals has been primarily derived from empirical use. There are no well-controlled clinical studies or efficacy trials to document clinical effectiveness.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
先確認精確活性成分、化學型態、釋放型態、成品、濃度與法域。 再確認物種、心臟表型、疾病階段、血流動力狀態、腎功能與全部併用治療。 由獸醫師建立個案途徑、方案、耐受性策略、監測、安全、生殖與雙邊交互作用契約。
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
70%
renal