Primaquine’s antiprotozoal mechanism of action is not well understood, but it may be related to it binding and altering protozoal DNA.
Primidone is indicated for seizure control (idiopathic epilepsy, epileptiform convulsions) in the dog. Because it is rapidly converted into phenobarbital in this species (see Pharmacokinetics below), and has a greater incidence of hepatotoxicity and behavioral effects, most neurologists do not recommend its use. However, some clinicians feel that some animals not responding to phenobarbital do benefit from primidone therapy, perhaps as a result that PEMA has been demonstrated to potentiate the anticonvulsant activity of phenobarbital in animals. When compared with phenobarbital, increased incidence of hepatotoxicity associated with primidone is considered the major limitation to long-term therapy with this agent. Primidone is considered more toxic in rabbits and cats than in humans or dogs.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
確認動物物種、病原種、地理與疾病嚴重度 確認是 primaquine phosphate、primaquine base 或其他表示基準 確認精確產品、劑型、濃度、調劑來源與給藥路徑 確認完整療程、支持治療、血液學與臨床監測計畫 確認氧化性溶血與高鐵血紅素風險、繁殖狀態及法域核准情形
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。