Quinacrine’s mechanism of action for its antiprotozoal activity against Giardia is not understood, however, it does bind to DNA by intercalation to adjacent base pairs thereby inhibiting RNA transcription and translocation. Additionally, quinacrine interferes with electron transport and inhibits succinate oxidation and cholinesterase. Quinacrine binds to nucleoproteins that (in humans at least) can suppress lupus erythromatosis (LE) cell factor.
Quinidine is used in small animal or equine medicine for the treatment of ventricular arrhythmias (VPCs, ventricular tachycardia), refractory supraventricular tachycardias, and supraventricular arrhythmias associated with anomalous conduction in WolffParkinson-White (WPW) syndrome. Chronic use of quinidine for controlling ventricular arrhythmias and supraventricular tachycardia in dogs has diminished over the years as other drugs appear to be more effective. It is still used in dogs and horses to convert atrial fibrillation to sinus rhythm. Oral therapy is generally not used in cats.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
現行 API 無法共同強制精確產品、鹽型/水合物、基質換算、物種、病原與臨床適應症、途徑、療程、法域、合法調劑、交互作用與監測。犬、貓與爬蟲三張歷史數值卡均缺必要 gate,因此全部只留在稽核檔,不進入計算器、處方或飼主端。
DRUGAPI 劑量審查引用的獸醫官方標示(各標示只適用於其產品、物種與法域,不可互換)
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。
renal