商品名:Mavik
Like other ACE inhibitors, it inhibits conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor and will stimulate sympathetic stimulation, renal hypertension, and synthesis of aldosterone. The ability of aldosterone to cause sodium and water retention contributes to congestion. Trandolapril, like other ACE inhibitors, will cause vasodilation and decrease aldosterone-induced congestion, but ACE inhibitors also contribute to vasodilation by increasing concentrations of some vasodilating kinins and prostaglandins. Trandolapril is converted to active trandolaprilat after administration.
Trandolapril, like other ACE inhibitors, is used for treatment of hypertension and for management of CHF. Compared to other ACE inhibitors, such as enalapril, it is not used commonly in veterinary medicine and the use has been derived from anecdotal experiences.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
任何執行前必須確認是群多普利單方或含維拉帕米的複方、完整商品與法域、是否為現行可得產品、物種、疾病與臨床狀態、血壓、循環容積與水合狀態、腎功能、血鉀、共同用藥、懷孕或繁殖狀態,以及非食用或食用動物法規;研究數值與來電者輸入不得回顯為建議。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。