商品名：Penicillin G potassium or sodium, Penicillin G
Beta-lactam antibiotic. Penicillin G is also called benzyl penicillin. Its action is similar to other penicillins. It binds penicillin-binding proteins (PBP) to weaken or cause lysis of the cell wall. Penicillin G is bactericidal with a time-dependent action. An increased bactericidal effect is observed when drug concentrations are maintained above minimum inhibitory concentration (MIC) values. The spectrum of penicillin G is limited to gram-positive bacteria, anaerobic bacteria, and a few highly susceptible gram-negative bacteria (e.g., Pasteurella spp.). Practically all bacteria of the Enterobacteriaceae and beta-lactamase–producing Staphylococcus spp. are resistant. Penicillin sodium or penicillin potassium when injected IV has a half-life of 1 hour or less in most animals. However, the
Penicillin G is administered by injection either IV (potassium or sodium penicillin) or IM (procaine or procaine/benzathine penicillin G). Penicillin G is indicated for treatment of gram-positive cocci that cause respiratory infections, abscesses, and urinary tract infections. Many staphylococci are resistant because of beta-lactamase synthesis. Streptococci are usually susceptible. Other susceptible organisms include gram-positive bacilli and anaerobic bacteria. Most gram-negative bacilli, especially those of enteric origin, are resistant. Some gram-negative respiratory pathogens such as Pasteurella multocida andMannheimia haemolytica are susceptible. Penicillin concentrations in the urine are at least 100-fold higher than plasma concentrations in treated animals; therefore, some urinary
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