Vitamin K1 is necessary for the synthesis of blood coagulation factors II, VII, IX, and X in the liver. It is believed that Vitamin K1 is involved in the carboxylation of the inactive precursors of these factors to form active compounds.
The principal uses of exogenously administered phytonadione is in the treatment of anticoagulant rodenticide toxicity. It is also used for treating dicumarol toxicity associated with sweet clover ingestion in ruminants, sulfaquinoxaline toxicity, and in bleeding disorders associated with faulty formation of vitamin K-dependent coagulation factors.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
先確認精確毒物或缺乏病因、出血嚴重度、凝血狀態、肝功能與是否需要支持療法。 逐一核對精確成品、濃度、賦形劑、物種、途徑、法域與可得性；不得跨成品轉移。 任何方案與停止時機均須由獸醫師依毒物持續性及重複凝血檢查個別決定。 注射途徑、過敏風險、懷孕泌乳與合併用藥須維持產品及病例限定。
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。