Torsemide, like furosemide inhibits sodium and chloride reabsorption in the ascending loop of Henle via interference with the chloride-binding site of the 1Na [+], 1K [+], 2Cl [-] cotransport system. Torsemide increases renal excretion of water, sodium, potassium, chloride, calcium, magnesium, hydrogen, ammonium, and bicarbonate. In dogs, excretion of potassium is affected much less so than is sodium (20:1); this is approximately twice the ratio of Na:K excreted than with furosemide. In cats, torsemide’s effects on potassium excretion appear to be similar to that of furosemide. In dogs, torsemide appears to have differing effects on aldosterone than furosemide. When compared to furosemide, torsemide increases plasma aldosterone levels and inhibits the amount of receptor-bound aldosterone, however, additional research must be performed to determine the clinical significance of these effects.
Torsemide is a loop diuretic similar to furosemide, but it is more potent, its diuretic effects persist for a longer period, and it does not cause as much potassium excretion (in dogs). While clinical use in dogs and cats thus far has been minimal, it potentially may be a useful adjunctive treatment for congestive heart failure in dogs and cats, particularly in patients that have become refractory to furosemide.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
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DRUGAPI 劑量審查引用的獸醫官方標示(各標示只適用於其產品、物種與法域,不可互換)
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。