商品名:Amikin
Amikacin, like the other aminoglycoside antibiotics, act on susceptible bacteria presumably by irreversibly binding to the 30S ribosomal subunit thereby inhibiting protein synthesis. It is considered a bactericidal concentration-dependent antibiotic. Amikacin’s spectrum of activity includes: coverage against many aerobic gram-negative and some aerobic gram-positive bacteria, including most species of _E. coli,_ Klebsiella _,_ Proteus _,_ Pseudomonas _,_ Salmonella _,_ Enterobacter _,_ Serratia _,_ and Shigella _,_ Mycoplasma _,_ and Staphylococcus. Several strains of _Pseudomonas_ _aeruginosa_, Proteus, and Serratia that are resistant to gentamicin will still be killed by amikacin. Antimicrobial activity of the aminoglycosides is enhanced in an alkaline environment. The aminoglycoside antibiotics are inactive against fungi, viruses and most anaerobic bacteria.
Treatment of susceptible bacterial infections in dogs and cats.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
腎功能調整:Extend interval to q48h or reduce dose in renal impairment; monitor levels
腎功能調整:Extend interval to q48h or reduce dose in renal impairment; monitor levels
現有犬 15–30 mg/kg 與貓 10–15 mg/kg 會把美國核准犬方案、不同犬貓感染指南、超標用途及固定療程混成通用計算,且缺產品、培養、感染部位、腎功能、水合、年齡與 TDM gate;一般計算與處方產生封鎖。
DRUGAPI 劑量審查引用的獸醫官方標示(各標示只適用於其產品、物種與法域,不可互換)
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。