Gentamicin has a mechanism of action and spectrum of activity (primarily gram-negative aerobes) similar to the other aminoglycosides. Like the other aminoglycoside antibiotics, it acts on suscep 420 gentamicin sulfate tible bacteria presumably by irreversibly binding to the 30S ribosomal subunit thereby inhibiting protein synthesis. It is considered a bactericidal concentration-dependent antibiotic. Gentamicin’s spectrum of activity includes coverage against many aerobic gram-negative and some aerobic gram-positive bacteria, including most species of _E. coli,_ Klebsiella _,_ Proteus _,_ Pseudomonas _,_ Salmonella _,_ Enterobacter _,_ Serratia _,_ and Shigella _,_ Mycoplasma _,_ and Staphylococcus. Several strains of _Pseudomonas_ _aeruginosa_, Proteus, and Serratia that are resistant to gentamicin may still be treated with amikacin. Antimicrobial activity of the aminoglycosides is enhanced in an alkaline environment. The aminoglycoside antibiotics are inactive against fungi, viruses and most anaerobic bacteria.
Treatment of susceptible bacterial infections in dogs and cats.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
腎功能調整：Contraindicated in renal impairment; if used, extend interval significantly
腎功能調整：Contraindicated in renal impairment; if used, extend interval significantly
確認精確產品／申請與法域、gentamicin base equivalent 濃度、物種／食用狀態、感染部位與培養／MIC、route、腎功能／水合／年齡、TDM 採樣、交互作用藥物、期間及產品專屬停藥期前，封鎖合併計算。
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。