商品名：Tapazole, Felimazole, Thiamazole, and generic.
Antithyroid drug. Action is to serve as substrate for thyroid peroxidase (TPO), to inhibit it and decrease incorporation of iodide into tyrosine molecules for the formation of thyroxine (T4) and triiodothyronine (T3). Methimazole inhibits coupling of mono-iodinated and di-iodinated residues to form T4 and T3. Methimazole does not inhibit release of preformed thyroid hormone. Methimazole does not affect existing thyroid hormones already circulating or stored in the thyroid gland and does not inhibit the peripheral conversion of T4 to T3. It generally takes 2 to 4 weeks for serum T4 to reach the
Methimazole is used to treat hyperthyroidism in animals, especially cats. There is good evidence for efficacy when administered to cats at recommended doses. Methimazole is preferred in cats instead of propylthiouracil (PTU) because methimazole has a lower incidence of adverse effects. Evidence supports twice-daily dosing in cats as more effective than once daily. Methimazole has been formulated for use in cats as a transdermal gel for skin absorption (e.g., those combined with pluronic organogel [PLO] gel). These formulations are available through compounding pharmacies. Published data indica
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
先確認貓的甲狀腺功能亢進診斷、臨床分組、共同疾病與治療目的 鎖定精確產品、劑型、濃度或強度、法域、標籤版本與供應者 依精確產品與患者狀況建立血液學、生化、甲狀腺與腎功能監測及停止規則 分開評估治療動物的繁殖風險與給藥者的懷孕、哺乳及暴露風險 所有換產品、換劑型、調整、暫停或改採根治療法均由獸醫師重新決定
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。