商品名:Serax
Benzodiazepine. Oxazepam is a central-acting CNS depressant with action similar to diazepam. Its mechanism of action appears to be via potentiation of GABA- receptor–mediated effects in the CNS. Oxazepam is one of the active products of metabolism from diazepam. In contrast to diazepam, oxazepam does not undergo extensive hepatic metabolism in animals, but it is glucuronidated before excretion. In dogs, oxazepam has a half-life of 5-6 hours, but these values were derived from administration of the parent drug diazepam. Oxazepam is eliminated by direct conjugation with glucuronide, without other intermediate metabolites produced, whereas diazepam and other benzodiazepines may produce other intermediate active metabolites.
Oxazepam is used for sedation and to stimulate appetite. The appetite-stimulating effects have been used, particularly in cats that may have diminished appetites caused by other primary diseases. As a benzodiazepine it also may be considered for behavior problems and anxiety disorders in animals, but it has not been used as commonly as other drugs.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
犬劑量缺乏公開直接臨床支持;貓的行為、旅行與歷史食慾方案也不能互換。產品、適應症、肝膽、呼吸、交互作用、依賴與管制藥閘門尚未建立。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。