商品名：Vasotop
Like other ACE inhibitors, ramipril inhibits conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor and will stimulate sympathetic stimulation, renal hypertension, and synthesis of aldosterone. The ability of aldosterone to cause sodium and water retention contributes to congestion. Ramipril, like other ACE inhibitors, will cause vasodilation and decrease aldosterone- induced congestion. ACE inhibitors also contribute to vasodilation by increasing concentrations of some vasodilating kinins and prostaglandins. There is evidence for a cardioprotective effect when used to treat dogs with heart disease caused by cardiomyopathy or valvular disease.
Ramipril is used to treat hypertension and congestive heart failure (CHF). It has not been studied as much as other ACE inhibitors in animals (e.g., enalapril or benazepril), but it is expected to have similar pharmacodynamic effects. It has been primarily used in dogs. It has also been used safely in cats to control hypertension but has not been effective for treating hypertrophic cardiomyopathy.
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