商品名:Cordarone
Antiarrhythmic drug, Class III. Antiarrhythmic effects are primarily caused by blocking the outward potassium channel in cardiac tissues. Amiodarone prolongs the action potential, delays myocardial repolarization, and delays the refractory period in cardiac tissues. It also may have some alpha-adrenergic receptor, beta-adrenergic receptor, and calcium-channel blocking properties. Half-life is several days in duration, and in some animals the half-life may be as long as 100 days with chronic therapy. In horses the terminal half-life was 38-84 hours. The intravenous formulation of amiodarone use
Amiodarone is used to treat refractory ventricular arrhythmias. It is reserved for treating life-threatening arrhythmias that have been refractory to other treatments. It has been used as a last resort for recurrent hemodynamically unstable ventricular tachycardia. In horses, IV amidarone has been used to treat atrial fibrillation.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
現行計算器會把負荷與維持期、犬貓馬、PO/IV、不同產品及賦形劑壓成單一數字。犬現行專業資料為負荷 8–10 mg/kg q12–24h 7–10 天後改 4–6 mg/kg q24h;貓只有 27 例回溯暴露且作者稱適當起始方案不明,馬是小型受監測研究。在物種、心律診斷、route、phase、精確產品/賦形劑、ECG/Holter、血壓與實驗室監測閉合前,封鎖所有通用計算與處方。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。