商品名：Coreg
Antiarrhythmic. Nonselective beta-receptor blocker. Carvedilol is a third-generation adrenergic blocker. Carvedilol blocks both beta1-receptors and beta2-receptors in heart and other tissues. Carvedilol is unique because it also has alpha-receptor– blocking properties that will produce vasodilation. It also is reported to have antioxidant properties. In dogs the half-life is short (1.2 hrs). Oral absorption is low and variable because of high systemic clearance and first-pass effects. Average oral absorption in one study was only 14% and highly variable, but in another study it was only 1.6% (
Carvedilol has been used to treat arrhythmias in animals. It is also used to treat systemic hypertension and to block beta-cardiac receptors in animals with rapid heart rates. Efficacy has been based on anecdotal accounts, extrapolation from humans, and limited studies in healthy dogs. In healthy dogs, 0.2 mg/kg PO decreased heart rate and 0.4 mg/kg PO decreased heart rate and lowered blood pressure. At 0.4 mg/kg, the effects in healthy dogs persisted for 36 hours. In other studies, doses of 0.3 mg/ kg were not effective. In clinical patients, the optimum dose is not known and long-term benefi
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
執行前必須由獸醫心臟專業判定精確物種、疾病與分期、血流動力穩定度、心率與血壓、節律與傳導、呼吸與心衰狀態、肝腎與血糖風險、完整併用藥、精確人用成品與調劑方式、個別調整與停藥規則、監測能力、法域及食用動物限制；缺一即維持封閉。
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。