商品名:Flovent
Potent glucocorticoid anti-inflammatory drug with potency of 18 times that of desamethasone. In patients with inflammatory airway diseases, glucocorticoids have potent anti-inflammatory effects on the bronchial mucosa. Glucocorticoids bind to receptors on cells and inhibit the transcription of genes for the production of mediators (cytokines, chemokines, adhesion molecules) involved in airway inflammation. A decrease in the synthesis of inflammatory mediators such as prostaglandins, leukotrienes, and platelet-activating factor caused by glucocorticoids also may be important. Glucocorticoids also play a role in enhancing the action of adrenergic agonists on beta-2 receptors in the bronchial smooth muscle, either by modifying the receptor or augmenting muscle relaxation after a receptor has
Fluticasone is used as an inhaled (topical) corticosteroid for treatment of airway disease. Most of the use has been established for cats, but it also could be used for dogs, horses, or other animals in which a special adapter can be used to deliver the drug via a metered-dose inhaler. In dogs and cats the most common use is for inflammatory airway diseases such as asthma, bronchitis, or bronchospasm. For example, if a cat is given 2 puffs twice a day of a potent inhaled corticosteroid (e.g., budesonide, fluticasone) and allowed 5-7 breaths (10 sec) from a chamber (spacer), it may reduce the need for oral prednisolone in cats with feline asthma. When doses were compared in experimental cats, the low dose of 44 mcg twice daily was as effective as 110 or 220 mcg twice daily. Fluticasone Prop
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
先確認為 fluticasone propionate;不得與 fluticasone furoate、其他類固醇、複方或相近名稱藥物混淆。 逐案確認精確成品、強度、metered 與 delivered 標示、推進劑、actuator、裝置、spacer、面罩、來源、法域與目前供應狀態。 由獸醫確認物種、精確氣道診斷、疾病期別、嚴重度、是否急性呼吸窘迫,以及感染、寄生蟲、結構性與心臟性等替代原因。 確認既有與併用類固醇、轉換計畫、內分泌與代謝共病、免疫狀態、肝臟、眼睛與骨骼風險。 犬、貓與馬研究只保留研究情境;不得把研究劑量、裝置步驟、時間點、cortisol 或偵測窗口轉成通用處方。 所有交互作用維持未評估;人用 strong CYP3A4 inhibitor 警語不能自動建立獸醫配對,no known interaction 也不能視為安全。 呼叫端體重、濃度、體積、頻率、期間、途徑、產品、裝置、適應症與疾病嚴重度全部忽略,不得形成計算、處方或飼主指示。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。