Some malignant cells are unable to synthesize asparagine and are dependent on exogenous asparagine for DNA and protein synthesis. Asparaginase catalyzes asparagine into ammonia and aspartic acid. The antineoplastic activity of asparaginase is greatest during the post mitotic (G1) cell phase. While normal cells are able to synthesize asparagine intracellularly, some normal cells having a high rate of protein synthesis, require some exogenous asparagine and may be adversely affected by asparaginase. Resistance to asparaginase can develop rapidly, but apparently, there is no cross-resistance between asparaginase and other antineoplastic agents. Asparaginase possesses antiviral activity, but its toxicity prevents it from being clinically useful in this regard.
Aspirin is used in all species for its analgesic and antipyretic effects. It is one of the few nonsteroidal antiinflammatory agents that is relatively safe to use in both dogs and cats, although it can cause significant GI bleeding in dogs. Besides its analgesic, antiinflammatory and antipyretic effects, aspirin is used therapeutically for its effects on platelet aggregation in the treatment of DIC and pulmonary artery disease secondary to heartworm infestation in dogs. It is also used in cats with cardiomyopathy. Aspirin (at low doses) may be of benefit in the adjunctive treatment of glomerular disease due to its antiplatelet and antiinflammatory activity.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
確認菌源、原生或修飾型態、製造來源與精確產品 確認活性單位定義，並確認複方產品或材料已有活性、純度與無菌性測試 確認物種、腫瘤類型、分期、既往曝露與完整合併方案 由獸醫腫瘤團隊建立個案風險與實驗室監測計畫 依精確產品與院內危險藥物政策處理與廢棄
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。