商品名：Arava and generic
Leflunomide is an isoxazole immunosuppressive drug. Leflunomide is not active as the parent drug, but it is converted to an active metabolite A77 1726 (also known as M1 and Teriflunomide), which inhibits T-cell and B-cell proliferation and is responsible for clinical immunosuppressive effects. It inhibits the synthesis of pyrimidine via inhibition of the enzyme dihydroorotate dehydrogenase. This enzyme is important for the de novo pyrimidine synthesis, which is critical for function of activated and stimulated lymphocytes. It also may produce anti-inflammatory effects by inhibiting proinflammatory cytokines. After oral absorption, the plasma levels of leflunomide are low or undetectable. Therapeutic effects are produced from the metabolite A77 1726 (M1) for the immunosuppressive action. If
This drug is used in people primarily for rheumatoid arthritis. In dogs it has been used for a variety of immune-mediated diseases as a substitute for other drugs such as azathioprine or mycophenolate. These diseases include myasthenia gravis, Evan’s syndrome, immune-mediated hemolytic anemia and thrombocytopenia, and polymyositis/polyarthritis. Efficacy has not been studied in controlled clinical studies but are reported anecdotal observations.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
確認來氟米特母體藥與 teriflunomide 活性代謝物或獨立產品的身分邊界。 確認確切產品、強度、賦形劑、品質與取得法規。 確認物種、診斷、嚴重度、並用治療、感染與疫苗背景。 建立個案化監測、停藥與異常處置計畫。 逐一人工評估所有共同用藥，受保護同儕不得由對側覆寫解除。
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
15 days
renal