商品名：Zonegran
Anticonvulsant. Mechanism of action is uncertain, but it may potentiate the action of GABA, an inhibitory neurotransmitter, or it may stabilize membranes and suppress propagation of seizures from an epileptic foci via changes in sodium and calcium conductance. Half-life in dogs has been reported to be approximately 15 hours in one study and 16 hours (plasma) to 57 hours (red blood cells [RBCs]) in another study. In cats, the half-life is longer than in dogs (33 hours).
Zonisamide is used to treat refractory seizures in dogs when other drugs have not been effective. It has been effective in experimentally induced seizures in dogs and in approximately 50% of dogs with refractory epilepsy. It has been used as an add-on with other anticonvulsant drugs such as phenobarbital and potassium bromide.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
在確認物種、癲癇分類與維持治療角色、精確產品／強度／法域、共用抗癲癇藥、肝腎功能、CBC、酸鹼／電解質、生殖狀態、TDM 與漸停計畫前，封鎖通用劑量計算、處方輸出與飼主可執行劑量。
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
renal