商品名：ProHeart (canine), Quest (equine), and Cydectin
Antiparasitic drug in the milbemycin class. Avermectins (ivermectin-like drugs) and milbemycins (milbemycin and moxidectin) are macrocyclic lactones and share similarities, including mechanism of action. Compared to ivermectin, moxidectin is 100 times more lipophilic. These drugs are neurotoxic to parasites by potentiating glutamate-gated chloride ion channels in parasites. Paralysis and death of the parasite are caused by increased permeability to chloride ions and hyperpolarization of nerve cells. These drugs also potentiate other chloride channels, including ones gated by GABA, but GABA-med
Moxidectin is used in dogs to prevent infection of heartworm (Dirofilaria immitis). In dogs it can be used to treat hookworm (Uncinaria stenocephala) in larval and 526 Moxidectin adult stages. In horses, moxidectin is used for treatment of a variety of parasites, including large strongyles (Strongylus vulgaris [adults and L4/L5 arterial stages], S. edentatus [adult and tissue stages], Triodontophorus brevicauda [adults], and T. serratus [adults]); small strongyles ([adults] Cyathostomum species, Cylicocyclus species, Cyliocostephanus species, Coronocyclus species, and Gyalocephalus capitatus).
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
先核對精確商品、全部有效成分、濃度、劑型、途徑、物種、年齡、體重與適應症。 分清完全核准、條件核准、簡化新藥申請與緊急使用授權；不得以成分索引取代現行標籤。 犬心絲蟲情境須完成獸醫健康評估與檢測，ProHeart 製品另受訓練認證及風險管理限制。 食用動物須逐一核對動物類別、奶用或屠宰限制、精確產品及當前停藥期。 抗藥性、治療失敗、共同用藥、轉運蛋白、生殖、幼齡與神經風險需由獸醫師個別評估。 系統不得自動產生計算、處方、替代、加量、補用、停藥期或飼主給藥指示。
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。