商品名：Motrin, Advil, and Nuprin
Like other NSAIDs in this class, ibuprofen produces analgesic and anti-inflammatory effects by inhibiting the synthesis of prostaglandins. The enzyme inhibited by NSAIDs is the cyclo-oxygenase enzyme (COX). The COX enzyme exists in two isoforms: COX-1 and COX-2. COX-1 is primarily responsible for synthesis of prostaglandins important for maintaining a healthy GI tract, renal function, platelet function, and other normal functions. COX-2 is induced and responsible for synthesizing prostaglandins that are important mediators of pain, inflammation, and fever. However, it is known that there is so
Ibuprofen is not registered for any animals in veterinary medicine. There are drugs in small animals that have been safer for the GI tract and are preferred. Use of ibuprofen in dogs is discouraged because of high risk of GI ulceration. It has been used for musculoskeletal inflammation in horses and ruminants. Administration of 25 mg/kg IV to cows reduced some systemic variables in endotoxin-induced mastitis. In horses, doses of 10-25 mg/kg have been used, but clinical trials of efficacy have not been reported.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
人用 ibuprofen 不作犬貓常規止痛藥；大型動物數字僅小型研究，且食用動物缺少殘留／停藥期閘門。
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。