商品名：CeeNu and CCNU
Anticancer agent. It is one of two nitrosoureas used: lomustine (1-[2-chloroethyl]-3- cyclohexyl-1-chloroethylnitrosourea), known by the abbreviation of CCNU, and carmustine (1,3-bis-2-chloroethyl-1-nitrosourea), known by the abbreviation BCNU. These drugs, in addition to being lipid soluble, are alkylating agents. Both of the nitrosoureas are metabolized spontaneously to alkylating and carbamyolating compounds. The binding occurs preferentially at the O-6 of guanine. Bifunctional interstrand cross-links are responsible for the cytotoxicity of nitrosoureas. Oral 440 Lomustine absorption and hi
Lomustine (CCNU) is used to treat tumors of the CNS, mast cell tumors, and lymphoma in dogs and cats. It has occasionally been used to treat other forms of cancer. Lomustine has been used more often than carmustine.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
犬貓公開方案皆依腫瘤、療程、膠囊與監測而定；現有通用 mg/m² 計算缺少診斷、BSA 雙人核對、精確膠囊來源／組合、血球低谷、累積肝毒及危害性藥物處理 gate。
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
renal