商品名:Minipress
Alpha1-adrenergic blocker. Prazosin is a vasodilator that is a selective blocker for the alpha1-adrenergic receptor, but it is not selective for either alpha-1a or alpha-1b. Its action is similar to phenoxybenzamine, but it produces less tachycardia than nonselective alpha-antagonist drugs. Prazosin decreases tension in both arterial and venous vascular smooth muscle. Prazosin relaxes smooth muscle, especially of vasculature. Prazosin is used as a vasodilator and to relax smooth muscle (occasionally urethral muscle). The alpha-1b adrenoreceptors regulate vascular tone and the alpha 1a-adrenore
Prazosin has been used in people for vasodilation and the management of hypertension that is not responsive to other drugs. Prazosin has been used to a limited extent in veterinary medicine to produce balanced vasodilation. There are no controlled studies to establish efficacy and dose, and indications are derived from anecdotal use and extrapolation from human medicine. It has also been used experimentally in horses to improve digital perfusion in the treatment of laminitis. Long-term administration is not common because tolerance may develop with chronic use.
劑量數字暫停提供:VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容,DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源;計算機可手動輸入劑量換算。
Prazosin 必須先區分物種、確切適應症、機械性與功能性阻塞、尿道通暢、體液與血壓/灌流、腎心共病、調劑濃度及併用降壓藥;貓常規再阻塞預防目前不一般建議。
依出現頻率分組;嚴重副作用獨立列出,臨床上需立即辨識。
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