Fluoroquinolones⛔ 高風險
Sucralfate chelates fluoroquinolones (enrofloxacin, marbofloxacin), reducing absorption by >50%; separate administration by at least 2 hours
Tetracyclines⛔ 高風險
Sucralfate chelates tetracyclines, dramatically reducing bioavailability; separate by 2+ hours
Sucralfate may reduce digoxin absorption; separate administration by 2 hours
Sucralfate reduces levothyroxine absorption; separate by 4+ hours
May decrease bioavailability of orally administered omeprazole
May decrease bioavailability of orally administered pantoprazole
Phenytoin⚠️ 中風險
Sucralfate may reduce phenytoin absorption; monitor serum levels
May inhibit absorption of difloxacin; separate doses of these drugs by at least 2 hours
May inhibit absorption of enrofloxacin; separate doses of these drugs by at least 2 hours
May inhibit absorption of ibafloxacin, separate doses of these drugs by at least 2 hours
May reduce absorption of ketoconazole
May inhibit absorption of marbofloxacin; separate doses of these drugs by at least 2 hours
May inhibit absorption of ciprofloxacin; separate doses of these drugs by at least 2 hours
May inhibit absorption of orbifloxacin; separate doses of these drugs by at least 2 hours
Oral sodium bicarbonate may reduce the efficacy of sucralfate if administered concurrently