商品名：Aldactone
Potassium-sparing diuretic. Action of spironolactone is to interfere with sodium reabsorption in distal renal tubule by competitively inhibiting the action of aldosterone. It binds directly to the aldosterone receptor, but at usual doses it does not block the action of other steroid receptors. It is more properly referred to as an aldosterone antagonist rather than a diuretic. It does not produce a significant diuretic action. There are minor antiandrogenic effects produced, but in animals these have not been clinically relevant. A related drug, eplerenone (Inspra) has been used in people beca
Spironolactone is used for treating high blood pressure and congestion caused by heart failure. It is approved in Europe (Prilactone) for dogs, to be used with standard therapy for the treatment of congestive heart failure caused by valvular disease. Spironolactone may be used with angiotensin-converting enzyme (ACE) inhibitors to achieve a synergistic effect for treatment of heart failure in animals. The proposed benefit is via aldosterone antagonism and can be used to inhibit the renin–angiotensin–aldosterone system (RAAS) activation that occurs from diuretic administration (e.g., furosemide
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
Spironolactone 的犬貓劑量依單方或固定複方、法域、物種、心臟病階段／其他適應症、隨餐要求、腎功能、鉀與鈉、繁殖狀態及併用心臟藥而不同；未通過全部條件前不得產生通用劑量。
DRUGAPI 劑量審查引用的獸醫官方標示（各標示只適用於其產品、物種與法域，不可互換）
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。
2 hours