商品名：Osmitrol
Hyperosmotic diuretic. Mannitol occurs naturally as a sugar in fruits and vegetables. As an osmotic diuretic, mannitol is freely filtered by the glomerulus, but it is not reabsorbed by the renal tubule. Therefore it increases osmolality of the urine. The osmotic effect inhibits reabsorption of fluid from the renal tubules, and this produces a natriuretic effect and strong diuresis. Reabsorption of sodium chloride Mannitol 453 M and solutes also is inhibited. Mannitol, compared to other diuretic drugs, produces a more profound diuretic effect, which can potentially cause excessive fluid loss in
Mannitol is administered IV for treatment of cerebral edema, acute glaucoma, and conditions associated with tissue edema. Mannitol also has been used to promote urinary excretion of certain toxins and in the management of anuric or oliguric renal failure.
劑量數字暫停提供：VetPro 的劑量改依 DRUGAPI 藥物資料庫對外的內容，DRUGAPI 目前不提供可直接計算的劑量。下方列出 DRUGAPI 的審查結論與劑量審查引用的來源；計算機可手動輸入劑量換算。
確認 D-mannitol 身分、精確品牌、成品、濃度、容器、溶液清澈與結晶狀態、賦形劑、製造商、批次、法域及當期核准與供應。 確認病患物種、品種、年齡、體重、生理與繁殖狀態、食用動物身分、精確診斷、顱內或眼內狀態、水合與容量、尿量、腎、心肺、神經與全部實驗室基線。 依精確成品與病患核對數值基礎、途徑、速率、時程、重複、上限、監測、停用、救援與轉診條件；本母體資料不得產生任何數值。 持續核對體液出入、電解質、酸鹼、滲透度或滲透間隙、腎功能、心肺與神經反應；不得採用 WSAVA 不需電解質監測句來放寬。 逐一核對所有藥物、補充品、液體、輸血、造影或麻醉相關處置；七個保護 peer 均須人工雙向裁決。 不得由 Segev 的錯誤圖說或稀釋與控制體積反推可執行單位、濃度或方案。
依出現頻率分組；嚴重副作用獨立列出，臨床上需立即辨識。